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Research output from our laboratory

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2025 6

Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis

Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota-Derived Indole-3-Propionic Acid

Piao Wang, Lan Yang, Lu Chen, Xinyu Huang, Zhen Lin, Yue Li, Caiyu Qi, Tianren Xu, Jianglin Zhang, Min Qi, Biao Cheng, Junjie Wang, Zhiqi Hu, Gaofeng Wang
Allergy, 2025
Published: 2025
🔗 DOI: 10.1111/all.16644 📝 Abstract
Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao
Advanced Science, 2025, 12(15): e2417593
Published: 2025
🔗 DOI: 10.1002/advs.202417593 📝 Abstract
The Role of Skin-Gut-Lung Microbiome in Allergic Diseases

The Role of Skin-Gut-Lung Microbiome in Allergic Diseases

Lan Yang, Zhen Lin, Ting Gao, Piao Wang, Gaofeng Wang
Journal of Allergy and Clinical Immunology: In Practice, 2025, 13(5): S2213-2198(25)00410-6
Published: 2025
🔗 DOI: 10.1016/j.jaip.2025.04.041 📝 Abstract
Early Life Risk Factors of Atopic March in a High-risk, Minority, Urban, Low-income, Prospective Birth Cohort

Early Life Risk Factors of Atopic March in a High-risk, Minority, Urban, Low-income, Prospective Birth Cohort

Gaofeng Wang, Junjun Chen, Joy Wan, Yuelong Ji, Chunhua Zhang, Evan Sweren, Sashank K Reddy, Xiaobin Wang, Luis A Garza, Xiumei Hong
Allergy, 2025, 79(5): 1351–1356
Published: 2025
🔗 DOI: 10.1111/all.15990 📝 Abstract
Melatonin treatment increases skin microbiota-derived propionic acid to alleviate atopic dermatitis

Melatonin treatment increases skin microbiota-derived propionic acid to alleviate atopic dermatitis

Lan Yang, Piao Wang, Ting Gao, Xinyu Huang, Zhen Lin, Evan Sweren, Yue Li, Lu Chen, Martin P Alphonse, Jianglin Zhang, Gaofeng Wang
Journal of Allergy and Clinical Immunology, 2025, 155(3): 880-891
Published: 2025
🔗 DOI: 10.1016/j.jaci.2024.11.019 📝 Abstract
Gut-X axis

Gut-X axis

Xu Lin, Zuxiang Yu, Yang Liu, Changzhou Li, Hui Hu, Jia-Chun Hu, Mian Liu, Qin Yang, Peng Gu, Jiaxin Li, Kutty Selva Nandakumar, Gaofei Hu, Qi Zhang, Xinyu Chen, Huihui Ma, Wenyehuang, Gaofeng Wang, Yan Wang, Liping Huang, Wenjuan Wu, Ning-Ning Liu, Chenhong Zhang, Xingyin Liu, Leming Zheng, Peng Chen
Imeta, 2025, 4(1): e270
Published: 2025
🔗 DOI: 10.1002/imt2.270 📝 Abstract

2024 4

Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with IOBR 2.0

Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with IOBR 2.0

Dongqiang Zeng, Yiran Fang, Wenjun Qiu, Peng Luo, Shixiang Wang, Rongfang Shen, Wenchao Gu, Xiatong Huang, Qianqian Mao, Gaofeng Wang, Yonghong Lai, Guangda Rong, Xi Xu, Min Shi, Zuqiang Wu, Guangchuang Yu, Wangjun Liao
Cell Reports Methods, 2024, 4(12): 100910
Published: 2024
🔗 DOI: 10.1016/j.crmeth.2024.100910 📝 Abstract
The Core-Shell Microneedle with Probiotic Extracellular Vesicles for Infected Wound Healing and Microbial Homeostasis Restoration

The Core-Shell Microneedle with Probiotic Extracellular Vesicles for Infected Wound Healing and Microbial Homeostasis Restoration

Fangfang Qi, Yujie Xu, Bowen Zheng, Yue Li, Jiarui Zhang, Zhen Liu, Xusheng Wang, Zhiyang Zhou, Dongqiang Zeng, Feng Lu, Chunhua Zhang, Yuyang Gan, Zhiqi Hu, Gaofeng Wang
Small, 2024, 20(46): e2401551
Published: 2024
🔗 DOI: 10.1002/smll.202401551 📝 Abstract
Commensal microbe regulation of skin cells in disease

Commensal microbe regulation of skin cells in disease

Yuyang Gan, Jiarui Zhang, Fangfang Qi, Zhiqi Hu, Evan Sweren, Sashank K Reddy, Lu Chen, Xinyi Feng, Elizabeth A Grice, Luis A Garza, Gaofeng Wang
Cell Host & Microbe, 2024, 32(8): 1264–1279
Published: 2024
🔗 DOI: 10.1016/j.chom.2024.07.020 📝 Abstract
Innate lymphoid cell-based immunomodulatory hydrogel microspheres containing Cutibacterium acnes extracellular vesicles for the treatment of psoriasis

Innate lymphoid cell-based immunomodulatory hydrogel microspheres containing Cutibacterium acnes extracellular vesicles for the treatment of psoriasis

Yujie Xu, Yuyang Gan, Fangfang Qi, Xinyu Lu, Xiaofei Zhang, Jiarui Zhang, Hailin Wang, Yue Li, Zhiyang Zhou, Xusheng Wang, Dongqiang Zeng, Feng Lu, Chunhua Zhang, Biao Cheng, Zhiqi Hu, Gaofeng Wang
Acta Biomaterialia, 2024, 184: 296-312
Published: 2024
📝 Abstract 🔗 DOI

2023 4

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy

Zhen Lin, Lu-yao Li, Lu Chen, Chen Jin, Yue Li, Lan Yang, Chang-zhou Li, Cai-yu Qi, Yu-yang Gan, Jia-rui Zhang, Piao Wang, Li-bin Ni, Gaofeng Wang
Acta Pharmacologica Sinica, 2023, 45(4): 815-830
Published: 2023
🔗 DOI: 10.1038/s41401-023-01193-5 📝 Abstract
N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma

N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma

Gaofeng Wang, Dongqiang Zeng, Evan Sweren, Yong Miao, Ruosi Chen, Junjun Chen, Jin Wang, Wangjun Liao, Zhiqi Hu, Sewon Kang, Luis A Garza
Journal of Investigative Dermatology, 2023, 143(8): 1579-1590
Published: 2023
🔗 DOI: 10.1016/j.jid.2023.01.027 📝 Abstract
Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

Gaofeng Wang, Zhen Lin, Yue Li, Lu Chen, Sashank K. Reddy, Zhiqi Hu, L.A. Garza
Advanced Drug Delivery Reviews, 2023
Published: 2023
🔗 DOI: 10.1016/j.addr.2023.114727 📝 Abstract
Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism

Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism

Gaofeng Wang, Evan Sweren, William Andrews, Yue Li, Junjun Chen, Yingchao Xue, Eric Wier, Martin P. Alphonse, Li Luo, Yong Miao, Ruosi Chen, Dongqiang Zeng, Sam Lee, Ang Li, Erika Dare, Dongwon Kim, Nathan K. Archer, Sashank K. Reddy, Linda Resar, Zhiqi Hu, Elizabeth A. Grice, Maureen A. Kane, Luis A. Garza
Science Advances, 2023, 9(1): eabo7555
Published: 2023
🔗 DOI: 10.1126/sciadv.abo7555 📝 Abstract

2022 1

Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection

Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection

Xintong Dong, Nathachit Limjunyawong, Elizabeth I Sypek, Gaofeng Wang, Roger V Ortines, Christine Youn, Martin P Alphonse, Dustin Dikeman, Yu Wang, Mark Lay, Ruchita Kothari, Chirag Vasavda, Priyanka Pundir, Loyal Goff, Lloyd S Miller, Wuyuan Lu, Luis A Garza, Brian S Kim, Nathan K Archer, Xinzhong Dong
Immunity, 2022, 55(9): 1645-1662
Published: 2022
🔗 DOI: 10.1016/j.immuni.2022.06.021 📝 Abstract

2021 2

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures

Dongqiang Zeng, Zilan Ye, Rongfang Shen, Guangchuang Yu, Jiani Wu, Yi Xiong, Rui Zhou, Wenjun Qiu, Na Huang, Li Sun, Xuejun Li, Jianping Bin, Yulin Liao, Min Shi, Wangjun Liao
Frontiers in Immunology, 2021, 12: 687975
Published: 2021
🔗 DOI: 10.3389/fimmu.2021.687975 📝 Abstract
Bacteria induce skin regeneration via IL-1β signaling

Bacteria induce skin regeneration via IL-1β signaling

Gaofeng Wang, Evan Sweren, Haiyun Liu, Eric Wier, Martin P Alphonse, Ruosi Chen, Nasif Islam, Ang Li, Yingchao Xue, Junjie Chen, Seungman Park, Yun Chen, Sam Lee, Yu Wang, Saifeng Wang, Nate K Archer, William Andrews, Maureen A Kane, Erika Dare, Sashank K Reddy, Zhiqi Hu, Elizabeth A Grice, Lloyd S Miller, Luis A Garza
Cell Host & Microbe, 2021, 29(5): 115-125
Published: 2021
🔗 DOI: 10.1016/j.chom.2021.03.003 📝 Abstract

2020 1

Association of the Psoriatic Microenvironment With Treatment Response

Association of the Psoriatic Microenvironment With Treatment Response

Gaofeng Wang, Yong Miao, Noori Kim, Evan Sweren, Sewon Kang, Zhiqi Hu, Luis A Garza
JAMA Dermatology, 2020, 156(10): 1057-1065
Published: 2020
🔗 DOI: 10.1001/jamadermatol.2020.2118 📝 Abstract

2019 1

Tumor Microenvironment Characterization in Gastric Cancer Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures

Tumor Microenvironment Characterization in Gastric Cancer Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures

Dongqiang Zeng, Meiyi Li, Rui Zhou, Jingwen Zhang, Huiying Sun, Min Shi, Jianping Bin, Yulin Liao, Jinjun Rao, Wangjun Liao
Cancer Immunology Research, 2019, 7(5): 737-750
Published: 2019
🔗 DOI: 10.1158/2326-6066.CIR-18-0436 📝 Abstract

2018 1

Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I-III colon cancer

Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I-III colon cancer

Rui Zhou, Jingwen Zhang, Dongqiang Zeng, Huiying Sun, Xiaoxiang Rong, Min Shi, Jianping Bin, Yulin Liao, Wangjun Liao
Cancer Immunology and Immunotherapy, 2018
Published: 2018
🔗 DOI: 10.1007/s00262-018-2289-7 📝 Abstract
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